基本资料

姓名：扈洪波                                            

性别：男                                              

职称：教授                                        

联系方式：

E-mail：hongbo@cau.edu.cn 

通信地址：北京市清华东路17号中国农业大学食品科学与营业工程学院

主要研究方向

1.  营养/食物因素对癌症形成的调控作用及其分子机制

2. 程序性细胞死亡(apoptosis, autophagy, necroptosis, paraptosis)的调控机制研究

3. 食品中内分泌干扰物质检测, 内分泌干扰毒性评价及毒理学机制

代表著作与论文

1） Hongbo Hu, Yubo Chai, Lei Wang, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, and Junxuan Lü Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells. Mol Cancer Ther October 2009 8:2833-2843

2） Hongbo Hu, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, Junxuan Lü Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. Carcinogenesis 2009； 30(5):818-23

3） Hongbo Hu, Hyo-Jeong Lee, Cheng Jiang, Jinhui Zhang, Lei Wang, Yan Zhao, Qiu Xiang, Sung-Hoon Kim and Junxuan Lu. Penta-1,2,3,4,6-O-galloyl-beta-D- glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther. 2008 Sep;7(9):2681-91

4） Hongbo Hu, Guang-Xun Li, Lei Wang, Jenifer Watts, Gerald F Combs and Junxuan Lü. Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down regulates anti-apoptotic proteins Bcl-XL and survivin. Clinical Cancer Research. 2008;14,1150-1158

5） Hongbo Hu, Cheng Jiang, Todd Schuster, Guang-Xun Li, Peter T. Daniel and Junxuan Lü. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther. 2006;5:1873-82. (Selected for oral presentation at the 2006 AACR Annual Meeting in Washington, DC).