张拓，博士，副教授。中国农业大学“优秀人才”。

电话：62736710

E-mail：zhangtuo@cau.edu.cn

研究方向：食品科学、食品营养与健康

教育经历

2008-2013，中国农业大学6163银河.net163.am，博士

2004-2008，中国农业大学6163银河.net163.am，本科

工作经历

2019-至今，中国农业大学6163银河.net163.am，副教授

2014-2019，美国密歇根州立大学，博士后

研究领域

1.      矿物质元素营养功能以及相关蛋白质功能活性

2.      受体及跨膜转运蛋白质等膜蛋白结构以及功能

教授课程

生物统计与实验设计（本科生），高等生物化学（AdvancedBiochemistry，留学研究生）

主持科研项目

国家自然科学基金-青年科学基金：矿物元素锌与其跨膜转运蛋白相互作用机制研究（31901638）

代表论文

1.      Tuo Zhang, EzizKuliyev, Dexin Sui, Jian Hu*. The Histidine-rich Loop in the Extracellular Domain of ZIP4 Binds Zinc and Plays a Role in Zinc Transport. Biochem. J., 2019 28;476(12):1791-1803.

2.      Bowen Zheng, Kai Zhou, Tuo Zhang, ChenyanLv, Guanghua Zhao*. Designed Two- and Three-Dimensional Protein Nanocage Networks Driven by Hydrophobic Interactions Contributed by Amyloidogenic Motifs. Nano Lett., 2019 19(6):4023-4028.

3.      Tuo Zhang, Jian Liu, Matthias Fellner, Chi Zhang, Dexin Sui, Jian Hu*. Crystal Structures of a ZIP Zinc Transporter Reveal a Binuclear Metal Center in the Transport Pathway. Sci. Adv., 2017 3(8):e1700344-54.

4.      Tuo Zhang, Dexin Sui, Jian Hu*. Structural Insights of ZIP4 Extracellular Domain Critical for Optimal Zinc Transport. Nat. Commun., 2016, 7(11979), 1-13.

5.      Chen Zhang¹, Tuo Zhang¹, Juan Zou¹, Cassandra Lynn Miller¹, RakshyaGorkhali, Jeong-Yeh Yang, Anthony Schilmiller, ShuoWang, Kenneth Huang, Edward M. Brown, Kelley W. Moremen, JianHu*, and Jenny J. Yang*. StructuralBasis for Regulation of Human Calcium-SensingReceptor by MagnesiumIons and an UnexpectedTryptophan Derivative Co-agonist. Sci. Adv.,2016, 2(5):e1600241-50. (co-first author).

6.      BenoitDesguin, Tuo Zhang, PatriceSoumillion, Pascal Hols, JianHu*, Robert P Hausinger*. METALLOPROTEINS. A tetheredniacin-derivedpincercomplex with a nickel-carbon bond in lactateracemase. Science, 2015, 349(6243), 66-69.

7.      Tuo Zhang, ChenyanLv, Lingli Chen, Guangling Bai, Guanghua Zhao*, ChuanshanXu. Encapsulation of anthocyaninmoleculeswithin a ferritinnanocageincreasestheirstability and celluptakeefficiency. Food. Res. Int., 2014, 62, 184-192.

8.      Meiliang Li, Tuo Zhang, Haixia Yang, Guanghua Zhao*, ChuanshanXu. A novelcalciumsupplementprepared by phytoferritinnanocagesprotectsagainstabsorptioninhibitorsthrough a uniquepathway. Bone, 2014, 64, 115-123.

9.      Tuo Zhang, Jiachen Zang, Shengli Zhang, Guanghua Zhao*. Application of FerritinModifiedEggshell Membrane in Heavy Metal IonUptake and Recovery. Conference Paper in Advanced MaterialsResearch 887-888, 596-600, January 2014.

10.  Rui Yang, Lingli Chen, Tuo Zhang, Senpei Yang, XiaojingLeng, Guanghua Zhao*.Self-assembly of ferritinnanocagesinto linear chainsinduced by poly(α, L-lysine). Chem. Commun., 2014, 50, 481-483. 

11.  Tuo Zhang, XiayunLiao, Rui Yang, ChuanshanXu, Guanghua Zhao*. Differenteffects of ironuptake and release by phytoferritin on starchgranules. J.Agric.FoodChem., 2013, 61(34), 8215-8223.

12.  Tuo Zhang, ChenyanLv, ShaojunYun, XiayunLiao, GuanghuaZhao*, XiaojingLeng*. Effect of high hydrostatic pressure (HHP) on structure andactivity of phytoferritin. Food Chem., 2012, 130(2), 273-278.

13.  Haixia Yang¹, Tuo Zhang¹, Taro Masuda, ChenyanLv, Lei Sun, Guiqin Qu, Guanghua Zhao*. Chitinase III in pomegranate seeds (Punicagranatum Linn.): a high-capacity calcium-binding protein in amyloplasts. Plant J., 2011, 68, 765-776 (co-first author).

14.  Xiayun Liao¹, Tuo Zhang¹, Qi Xiao, Huabin Yang, Guanghua Zhao*, XiaojingLeng*. Different effects of temperature on supramolecular protein and non-protein materials in hydrogen storage. Int. J. Hydrogen Energy, 2012, 38, 991-998 (co-first author).

15.  Shaojun Yun, TuoZhang,Meiliang Li, Bin Chen, Guanghua zhao*. Proanthocyanidins inhibit iron absorption from soybean(Glycine max) seed ferritin in rats with iron deficiency anemia. Plant Food. Hum. Nutr., 2011, 66, 212-217.